Select correct option for given statements:
(i) At present, about 30 recombinant therapeutics have been approved for human-use all over the world and all 30 are presently being marketed in India.
(ii) Insulin used for diabetes was earlier extracted from pandcreas of living cattle and pigs.
(iii) Insulin from an animal source, though caused some patients to develop allergy or other types of reactions to the foreign protein.
(iv) Insulin consists of two short polypeptide chains: chain A and chain B, that are linked together by disulphide bridges.
(v) In mammals, including humans, insulin is synthesized as a pro-hormone, insulin is synthesized as a pro-hormone which contains an extra stretch called the C peptide.
(vi) The C peptide is not present in the mature insulin and is removed during maturation into insulin.
Text Solution
Verified by ExpertsA
(i) Incorrect — only about 30 recombinant therapeutics are approved worldwide, but not all are marketed in India
(ii) Correct — insulin was earlier extracted from cattle and pigs
(iii) Correct — animal insulin caused allergic reactions in some patients
(iv) Correct — insulin has A and B chains linked by disulfide bonds
(v) Correct — insulin is synthesized as proinsulin with C-peptide
(vi) Correct — C-peptide is removed in mature insulin
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